The heterotetradimers are fashioned following the conversation of UPK2 and UPK3A moieties of your heterodimers. adhering to assembly within the endoplasmic reticulum and also the Golgi, 6 heterotetradimers organized in inner and outer rings68 form a 16?nm AUM particle or plaque (Fig. 3), packaged into DFVs and shipped to the apical membrane69. The